A REVIEW OF BLISOVI FE 1/20

Sulfates are the key circulating conjugates of ethinyl estradiol and glucuronides predominate in urine. The primary oxidative metabolite is two-hydroxy ethinyl estradiol, shaped through the CYP3A4 isoform of cytochrome P450. Component of the 1st-go metabolism of ethinyl estradiol is considered to happen in gastrointestinal mucosa. Ethinyl estradiol